Why Bioidentical Hormone Pellets Are the Gold Standard in BHRT

Ladies, pull up a chair—preferably one that isn’t vinyl—because if you're in the middle of a hot flash, you might stick to it. I’ve spent the last 30 years treating women who’ve been dismissed, misdiagnosed, or handed a prescription that did little more than turn them into a slightly more tired version of themselves. And after all these years women’s hormonal health, one thing has
remained crystal clear:
Bioidentical hormone pellets are the gold standard in hormone replacement therapy.
Let me explain why—doctor-to-patient, woman-to-woman, survivor-to-survivor.
“Bioidentical hormone pellets are physiologically the same as our own bodies’
hormones, and they provide the best and most consistent delivery and results.”
– Angela DeRosa, DO, MBA, CPE
If you’ve ever been told by your healthcare provider that your hot flashes, weight gain, brain fog, low libido, anxiety, or sleep issues are “just part of getting older,” it’s time to find a new doctor who truly understands perimenopause and menopause symptoms and how to address the root cause. Hormonal decline isn’t a character-building exercise; it’s a medical condition. And just like any medical condition, it deserves evidence-based, individualized, effective treatment.
Bioidentical hormones, particularly ones in the form of pellets, are the closest thing we have to restoring your hormones to the levels Mother Nature originally designed for you.
What Makes Pellets “Bioidentical”?
“Bioidentical” means the hormones are identically structured to the hormones your body naturally produces. Most bioidentical hormones are plant-based, including estradiol, progesterone, and testosterone.
Synthetic hormones, on the other hand, are chemically altered forms of hormones, some of which come from the urine of pregnant horses. These hormones aren’t a perfect molecular match with your natural hormone receptors, and this makes a difference to your body at a cellular level.
Your body recognizes bioidentical hormones as its own. Delivered in the form of pellets, which bypass your digestive system, this form of hormones has the potential to:
● Work better
● Have fewer side effects
● Allow your body to metabolize hormones the way it’s supposed to
● Reduce cardiovascular risks
● Protect breast tissue
Think of it like this: if bioidentical hormones were puzzle pieces to the cells in your body, they would provide the matching pieces for the exact fit (and therefore, potential for maximum benefits).
Why Pellets? Let Me Count the Ways…
You can get bioidentical hormones in many forms, including topical creams and gels; oral tablets and troches; injectables, and pellet implants. There are so many forms and dosage strengths that can be customized for your individual needs through compounded hormones. So why do I champion pellets? Why are they the gold standard in hormone replacement therapy?
It’s really quite simple: the delivery system matters.
A Ferrari filled with cheap gas is still a Ferrari, but it’s not going to run well. And, you're probably not going to get it up to speed with its engine purring. When prescribed correctly, think of pellets as the premium fuel of hormone therapy; the type of fuel that can rev up your menopausal body so it runs smoothly again. Let’s look at some reasons why.
1. Pellets Give You Steady, Consistent Hormones
Topicals and orals can create hormonal roller coasters, leaving you feeling like you’re starring in a soap opera you didn’t audition for. Sometimes your symptoms might subside, and sometimes you might feel miserable. That’s because how well your body absorbs topical hormones through your skin, or oral hormones that have to pass through your digestive system, can fall short and
even cause unpleasant side effects.
Pellets on the other hand offer more of a slow-release infusion of hormones. They dissolve into your bloodstream at the perfect rate, giving you:
● Lower instance of spikes and crashes
● Less worry about forgetting to rub on your cream each day
● No worrying if your husband, kids, or dog will accidentally get a dose of estrogen because they came into contact with your skin
Pellets are essentially the “set it and forget it” form of hormone therapy.
2. Pellets Are the Only Delivery Method That Truly Mimics Ovarian Function
Before perimenopause and menopause, your ovaries didn’t just release hormones once a day. They released hormones steadily, continuously, in rhythm with your body’s needs. Pellets replicate that. Nothing else comes as close.
3. Pellets Bypass the Liver (Your Liver Says “Thank You!”)
Oral hormones have to go through the liver, which can increase inflammation and impact clotting factors, especially if you are a smoker. Pellets go straight into your bloodstream, skipping the liver processing.
4. No Mess, No Fuss, No “Oops, I Forgot”
We’re all busy. As women, we often juggle careers, kids, marriages, divorces, pets, aging parents, and (my personal favorite) uneducated doctors who still think women don’t need testosterone.
Pellets help take daily compliance off your plate. Once inserted during a quick, easy, in-office procedure (you’ve undoubtedly had pap smears that were more unpleasant!), pellets offer your body a steady dose of hormones for the next 3 to 5 months.
5. The Results Are Often Much Better Than Other Forms of Hormones
I’ve seen thousands of women get their lives back (and then some) with the right combination and doses of hormone pellets, including:
● Boosted libido
● Improved sleep
● Less anxiety
● More energy
● Disappearing hot flashes
● Weight loss
● More even moods
● Less brain fog
● Happier relationships
In most cases, when women’s hormones are optimized and stable, everything else follows suit.
Pellet Myths I Hear All the Time
You’ve probably heard them too, so let’s bust a few myths while we’re here, shall we?
“Pellets are dangerous.”
This is simply not true. What is dangerous is walking around chronically hormone-depleted for decades. That’s what accelerates aging, increases disease risk (including cardiovascular, bone, and brain), and drains your quality of life.
“Pellets make you grow a beard.”
While increased facial hair growth may be a potential side effect of increasing your testosterone levels, experienced pellet providers (key piece of the puzzle) know how to adjust your hormone doses to minimize that. As I’ve said before, if someone offered you a million dollar home for free, but you were responsible for mowing the lawn every week, would you say: “No
thanks! I don’t need the house of my dreams. It’s not worth the maintenance!”
If you have to wax your mustache for a couple months while your body gets used to feeling wonderful from the inside out, I’d say it’s a fair trade off. And, most likely, the extra hair growth will regulate itself, too—IF you even experience it at all.
“I heard pellets aren’t FDA-approved.”
Compounded hormone pellets are made with FDA-approved ingredients, and are highly regulated and held to their own set of standards within the compounding industry. It’s also a little-known fact that hormone pellet therapy has been in use since the 1930s. It’s not something new that hasn’t been scientifically and clinically studied. In fact, pellets and their positive effects
on overall health, have been studied significantly in the last several decades.
Why I’ve Dedicated My Career to Helping Women through Menopause
For decades, mainstream medicine has misunderstood women’s hormones, under-treated women’s symptoms, and over-prescribed antidepressants, sleeping pills, and anti-anxiety meds instead of addressing the root cause—hormonal decline.
I was tired of watching women suffer.
I was tired of seeing women brushed off (myself included).
And frankly, I’m still tired of the inaccurate information being fed to women.
So I wrote my book, started teaching physicians, and dedicated my career to getting bioidentical hormone replacement therapy into the hands of women who deserve better.
If You’re Struggling, Please Know This: You Are Not Crazy
You’re not imagining your symptoms. You’re not “just stressed.” You’re not “just aging.”
Your hormones matter. Your health matters. YOU matter.
Pellet therapy isn’t just about optimizing hormones—it’s about giving women their lives back.
After 30 years and thousands of patients, I can confidently say: Bioidentical hormone pellets are truly the gold standard in hormone therapy; the most transformative method of BHRT.
Your ovaries may be retired…but with pellet therapy, your vitality doesn’t have to be.
As someone who has treated more than 20 thousand patients in the last 30 years, and written about BHRT, you might find my book, A Woman’s Hormonal Health Survival Guide: How to Prevent Your Doctor from Slowly Killing You, a helpful tool in your perimenopause journey
and beyond.
Read more about hormone delivery methods, including pellets in
Chapter 8: Giving Back What Mother Nature Intended Us to Have: Treatment Options
Explore the differences of synthetic vs. bioidentical hormones in
Chapter 2: Challenges, Myths and Misconceptions About HRT
The Doctor is in!




